Pathological analysis of epithelial cells in periodontitis

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Periodontitis is a bacterial infectious disease that destroys gingival epithelial cells, and develops inflammation of immune-related cells. However, pathological studies on epithelial cells in periodontitis have been less frequently performed compared to those of immune-related cells. In this study, we focused on lysosomal abnormalities, because gene mutants of lysosomal proteins such as cathepsin C and Lyst causes severe periodontal diseases in human．Therefore, we analyzed epithelial cells in cathepsin C deficient mice and Lyst mutant mice (beige mouse) infected by Porphyromonas gingivalis, a major periodontal pathogen, in order to clear the physiological and pathological roles of epithelial cells in periodontitis.