The role of 11β-HSD1, an intracellular glucocorticoid-activating enzyme, in periodontal disease

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It has been suggested that 11β-hydroxysteroid dehydrogenase type1 (11β-HSD1), a glucocorticoid-activating enzyme, plays an important role in metabolic syndrome. Although the relationship between periodontal disease and metabolic syndrome has been established, the involvement of 11β-HSD1 in periodontal disease has not been reported. This study was performed to elucidate the role of 11β-HSD1 in periodontal disease. As a result, a statistically significant increase of 11β-HSD1 mRNA expression was detected in the periodontal disease group compared with the controls. Furthermore, the depth of periodontal pockets significantly correlated with the increased expression of 11β-HSD1 mRNA. These results suggest that the increased expression of 11β-HSD1 may play a role in the progression of periodontal disease.