The role of 11β-HSD1, an intracellular glucocorticoid-activating enzyme, in periodontal disease

细胞内糖皮质激素激活酶 11β-HSD1 在牙周病中的作用

• 批准号: 22592105
• 负责人: SAWAI Hirofumi
• 金额: $ 2.33万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592105/
• 关键词: 歯周病; メタボリックシンドローム; 11β-HSD1; グルココルチコイド

It has been suggested that 11β-hydroxysteroid dehydrogenase type1 (11β-HSD1), a glucocorticoid-activating enzyme, plays an important role in metabolic syndrome. Although the relationship between periodontal disease and metabolic syndrome has been established, the involvement of 11β-HSD1 in periodontal disease has not been reported. This study was performed to elucidate the role of 11β-HSD1 in periodontal disease. As a result, a statistically significant increase of 11β-HSD1 mRNA expression was detected in the periodontal disease group compared with the controls. Furthermore, the depth of periodontal pockets significantly correlated with the increased expression of 11β-HSD1 mRNA. These results suggest that the increased expression of 11β-HSD1 may play a role in the progression of periodontal disease.

11β-羟基类固醇脱氢酶1（11β-hydroxysteroid dehydrogenase type 1，11β-HSD 1）是一种糖皮质激素激活酶，在代谢综合征中起重要作用。虽然牙周病与代谢综合征之间的关系已被确定，但11β-HSD 1在牙周病中的作用尚未见报道。本研究旨在阐明11β-HSD 1在牙周病中的作用。结果显示，牙周病组11β-HSD 1 mRNA表达较对照组显著增加。牙周袋深度与11β-HSD 1 mRNA表达水平显著相关。提示11β-HSD 1的高表达可能在牙周病的发生发展中起一定作用。

项目成果

一酸化窒素(NO)による実験的歯の移動の促進

一氧化氮 (NO) 促进实验性牙齿移动

• 发表时间: 2011
• 作者: 石幡浩志;小林洋子 他;片尾祐子;小林洋子 他;宍戸美香
• 通讯作者: 宍戸美香

Effect of long acting nitric oxide donors on the differentiation of osteoclasts derived from mouse bone marrow macrophages

长效一氧化氮供体对小鼠骨髓巨噬细胞来源破骨细胞分化的影响

• 发表时间: 2010
• 期刊: Journal of Osaka Dental University
• 作者: Kaoru Inami;Hirofumi Sawai;Yuko Katao; Mika Shishido;Yousuke Ujii;Misa Shimozuma; Kensuke Nobata;Naochika Domae;Naoyuki Matsumoto
• 通讯作者: Naoyuki Matsumoto

Effect of long acting nitric oxide donors on the differentiation of osteoclasts derived from mouse bone marrow macrophages.

长效一氧化氮供体对小鼠骨髓巨噬细胞来源的破骨细胞分化的影响。

• 发表时间: 2010
• 期刊: J Osaka Dent Univ
• 作者: Nagayama T;Seiryu M;Deguchi T;Kano M;Suzuki T;Takano-Yamamoto T;Ichikawa H;Inami K.
• 通讯作者: Inami K.

Induction of osteoclast differentiation by NOC-18, a long-acting nitric oxide donor

长效一氧化氮供体 NOC-18 诱导破骨细胞分化

• 发表时间: 2012
• 作者: 佐塚 泰之;Kaoru Inami
• 通讯作者: Kaoru Inami

Effects of nitric oxide(NO) on experimental tooth movement

一氧化氮（NO）对实验性牙齿移动的影响

• 发表时间: 2012
• 作者: N. Endo;Y. Iwamatsu‐Kobayashi;N. Iwama;H. Ishihata;H. Shimauchi;M. Kikuchi;Mika Shishido
• 通讯作者: Mika Shishido