Inhibition of NFκB activity by MALT1 and its involvement in phenotypic alterations of oral carcinoma cells

MALT1 对 NFκB 活性的抑制及其与口腔癌细胞表型改变的关系

• 批准号: 22592103
• 负责人: IMAI Kazushi
• 金额: $ 3万
• 依托单位: The Nippon Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592103/
• 关键词: 口腔癌; MALT1

The present study examined a role of mucosa-associated lymphoid tissue 1 (MALT1), whose expression is inactivated in oral carcinomas with worse prognosis, in oral carcinoma cells and its involvement in phenotypic alteration of the cells by the microarray and proteomic analyses. MALT1 down-regulated expression of genes in the TGF-ss and EGF pathways, alternated keratin species involved in aggressive feature of carcinoma cells, and suppressed proliferation and migration of the cells. Furthermore, E-cadherin-mediated carcinoma cell-cell adhesion machinery, which was also strongly down-regulated by MALT1, was rapidly obstructed with progression of oral carcinomas.

本研究探讨了粘膜相关淋巴组织1（MALT 1），其表达失活的口腔癌预后较差，在口腔癌细胞和其参与的表型改变的细胞的微阵列和蛋白质组学分析的作用。MALT 1下调TGF-β和EGF途径中的基因表达，改变参与癌细胞侵袭特征的角蛋白种类，并抑制细胞的增殖和迁移。此外，E-钙粘蛋白介导的癌细胞-细胞粘附机制，这也是强烈下调MALT 1，口腔癌的进展迅速受阻。

项目成果

Inhibition of TGF- and EGF pathway gene expression and migration of oral carcinoma cells by mucosa-associated lymphoid tissue 1.

粘膜相关淋巴组织抑制 TGF-和 EGF 通路基因表达和口腔癌细胞迁​​移 1.

• 期刊: Br J Cancer
• 作者: Ohyama Y;Kawamoto Y;Chiba T;Maeda G;Sakashita H;Imai K
• 通讯作者: Imai K

口腔癌進展のメカニズムと分子標的薬

口腔癌进展机制及分子靶向药物

• 发表时间: 2013
• 期刊: 歯学
• 作者: 今井一志;須藤遥;前田元太;千葉忠成
• 通讯作者: 千葉忠成

MALT1-responsive keratin rearrangement and proliferation of oral carcinoma cells.

MALT1 响应性角蛋白重排和口腔癌细胞增殖。

• 发表时间: 2013
• 作者: Kawamoto H;Ohyama Y;Chiba T;Yagishita H;Sakashita H;Imai K.
• 通讯作者: Imai K.

口腔扁平上皮癌細胞におけるMALT1誘導タンパク質のプロテオーム解析

口腔鳞状细胞癌细胞中 MALT1 诱导蛋白的蛋白质组学分析

• 发表时间: 2011
• 作者: 川本幸寛

Proteomic identification of keratin alterations with enhanced proliferation of oral carcinoma cells by loss of mucosa-associated lymphoid tissue 1 expression.

• DOI: 10.3892/ijo.2013.1990
• 发表时间: 2013-09
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: Y. Kawamoto;Y. Ohyama;T. Chiba;H. Yagishita;H. Sakashita;K. Imai