Inhibition of NFκB activity by MALT1 and its involvement in phenotypic alterations of oral carcinoma cells

本研究探讨了粘膜相关淋巴组织1（MALT 1），其表达失活的口腔癌预后较差，在口腔癌细胞和其参与的表型改变的细胞的微阵列和蛋白质组学分析的作用。MALT 1下调TGF-β和EGF途径中的基因表达，改变参与癌细胞侵袭特征的角蛋白种类，并抑制细胞的增殖和迁移。此外，E-钙粘蛋白介导的癌细胞-细胞粘附机制，这也是强烈下调MALT 1，口腔癌的进展迅速受阻。

The present study examined a role of mucosa-associated lymphoid tissue 1 (MALT1), whose expression is inactivated in oral carcinomas with worse prognosis, in oral carcinoma cells and its involvement in phenotypic alteration of the cells by the microarray and proteomic analyses. MALT1 down-regulated expression of genes in the TGF-ss and EGF pathways, alternated keratin species involved in aggressive feature of carcinoma cells, and suppressed proliferation and migration of the cells. Furthermore, E-cadherin-mediated carcinoma cell-cell adhesion machinery, which was also strongly down-regulated by MALT1, was rapidly obstructed with progression of oral carcinomas.