Inhibition of NFκB activity by MALT1 and its involvement in phenotypic alterations of oral carcinoma cells

本研究通过基因芯片和蛋白质组学分析，研究了在预后较差的口腔癌中表达失活的粘膜相关淋巴组织1(MALT1)在口腔癌细胞中的作用及其与细胞表型变化的关系。MALT1下调了转化生长因子-生长因子和表皮生长因子途径中基因的表达，改变了参与癌细胞侵袭性的角蛋白物种，抑制了细胞的增殖和迁移。此外，E-钙粘素介导的癌细胞-细胞黏附机制也被MALT1强烈下调，随着口腔癌的进展而迅速受阻。

The present study examined a role of mucosa-associated lymphoid tissue 1 (MALT1), whose expression is inactivated in oral carcinomas with worse prognosis, in oral carcinoma cells and its involvement in phenotypic alteration of the cells by the microarray and proteomic analyses. MALT1 down-regulated expression of genes in the TGF-ss and EGF pathways, alternated keratin species involved in aggressive feature of carcinoma cells, and suppressed proliferation and migration of the cells. Furthermore, E-cadherin-mediated carcinoma cell-cell adhesion machinery, which was also strongly down-regulated by MALT1, was rapidly obstructed with progression of oral carcinomas.