Relations between sensation and innervation of dental pulp in patients with hereditary sensory and autonomic neuropathy(HSAN).

通过电髓测试（EPT），遗传性感觉和自主神经病变（HSAN-IV）患者的牙齿没有任何感觉，而HSAN-V患者的牙齿有与正常人相似的疼痛前感觉。在hsan - ivv病例中仅观察到少量髓鞘纤维，而在hsan - v患者的牙髓中发现了许多髓鞘纤维。本研究结果表明，牙髓神经支配明显减少可能导致HSAN-IV型小鼠对疼痛的先天性不敏感。

By electrical pulp tester (EPT), patients with hereditary sensory and autonomic neuropathy (HSAN-IV)cases did not feel any sensation at all in their teeth, but HSAN-V cases felt the pre-pain sensation similar to a normal person. Only a few myelinated fibers were observed in HSAN-IVcases, on the other hand, many fibers were identified in the dental pulp of patients withHSAN-V. The present result shows that remarkably reduced pulpal innervation might induce congenitalinsensitivity to pain in HSAN-IV.