Establishment of therapeutic strategy for endo-perio lesion; the control of complement regulatory factors

补体调节因子(CD46、CD55和CD59)在人牙周膜细胞中表达。人牙周膜细胞在脂多糖刺激下表达CD59的量可被肿瘤坏死因子-1处理后下调。内源性大麻酰胺(AEA)可诱导人牙髓细胞产生基质金属蛋白酶-2。基质金属蛋白酶-2可能是从细胞中切割补体调节因子，并受到补体攻击。炎症介质如肿瘤坏死因子-α和内源性大麻素如AEA可能下调补体调节因子的表达，可能是导致根尖区组织破坏的原因。

Complement regulatory factors (CD46, CD55, and CD59) were expressed in human periodontal ligament cells. The amount of CD59 expressed on human periodontal ligament cells stimulated with LPS from P. intermediais down-regulated by pre-treatment with TNF- . Anandamide (AEA), one of endocannabinoids, induced MMP-2 production in human dental pulp cells. MMP-2 might be cleave the complement regulatory factors from cells, and which receive complementary attack. It is likely that inflammatory mediatorssuch as TNF- and endocannabinoids such as AEA down-regulate the expression of complement regulatory factors and might be cause the tissue destruction inapical region.