Fabrication of apatite bone substitutes designed on bone tissue compatibility

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In order to increase an ability of bone replacement for carbonate apatite bone substitutes, an integrated design including pore incorporation as well as chemical composition and crystallinity was examined in this study. 10wt% spherical PMMA particles was introduced into gypsum hardening body and burned out then subsequently hydrothermally treated with carbonate solution to obtain the precursor porous body consisting of calcite. The precursor could transform to carbonate apatite with enough handling property. In vivo experiment using rats indicated the incorporation of new bone into the pore structure of the obtained porous body. It was concluded that the present method using spherical PMMA particles would be useful to make design of porous structure for carbonate apatite bone substitutes.