The elucidation of a mechanotransduction mechanism to the joint destruction in the temporomandibular joint synovial cell

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In this study, the mechanical stress considered to participate in development of symptoms and advance of temporomandibular disorder was added to the human temporomandibular joint synovial cells, and the elucidation of the mechanotransduction mechanism in a synovial cell. Since the cultured cell became extinct under the influence of the Great East Japan Earthquake, although it did not result in the elucidation of sufficient signal transfer, promotion of formation and the mechanism of the osteoclast by compression stimulus of the synovial cells were clarified.