Approach to the elucidation of bone regeneration mechanism -the effect of hyperbaric oxygen environment on bone metabolism

在本研究中，我们在细胞水平和动物模型上分析了高压氧环境对骨再生的各种影响。在细胞水平上，提示高压空气环境和高浓度氧环境对破骨细胞增殖分化的影响不同。在动物模型中，高浓度氧环境在骨再生初期促进新骨的形成，而高压空气环境抑制新骨的形成是相互矛盾的。在反映两种环境影响的同时，表明高压氧环境对骨再生的影响是复杂的。

In this study, we analyzed for the various effects of hyperbaric oxygen environment affected the bone regeneration at the cellular level and animal models. At the cellular level, it suggested that hyperbaric air environment and high concentration oxygen environment were affected the different effects on the proliferation and differentiation of osteoclasts. In animal models, it was shown the conflicting effects that high concentration oxygen environment promotes new bone formation in initial period of bone regeneration, and hyperbaric air environment inhibits new bone formation. While reflecting the effects of both environments, it suggested that hyperbaric oxygen environment affects intricately to the bone regeneration.