Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug

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A new magnetic anticancer drug (=New drug) was developed giving an anti-tumor effect by fragmenting DNA and controlling cell proliferation, depending on its density. The New drug is characterized by being a magnetic substance, which accumulates locally through impression of a magnetic field using a permanent magnet. As a result, it could be used as a drug delivery system. In addition, it was clarified that the New drug generates heat because of the high frequency magnetic field impression; thus, it is expected to be effective for intra-tissue hyperthermia.We performed a comparative MTT assay assessing the antitumor effects of the New drug against cisplatin(CDDP), an anticancer drug mainly used for oral cancer. We also created a tongue tumor model into which the VX2 cell line was transplanted, and performed an animal experiment using the New drug. This result suggests that EI236 become a new drug for the treatment of oral cancer.