Reaction of HPA-axis and brain cytokines in oral inflammation model

口腔炎症模型中 HPA 轴和脑细胞因子的反应

• 批准号: 22592258
• 负责人: MAEDA Shigeru
• 金额: $ 2.91万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592258/
• 关键词: 炎症; ストレス反応; HPA axis; 視床下部; CRH; 糖質コルチコイド; 副腎皮質ステロイド; 視床下部室傍核; LPS; 歯科

Depression can be induced by an activation of stress reaction related with infection, injury, etc. Since oral area is a favorite site for inflammation, affect of oral inflammation on both inflammatory reaction and stress reaction, was evaluated in this study. As a result, stress reaction was induced in oral inflammatory model, and it is suggested that stress related with inflammation may be controlled by an opioid.

抑郁症可以通过与感染、损伤等相关的应激反应的激活来诱导。由于口腔区域是炎症的最佳部位，因此本研究评估了口腔炎症对炎症反应和应激反应的影响。结果表明，口腔炎症模型可诱导应激反应，提示与炎症相关的应激反应可能受阿片类物质的调控。

项目成果

Valproate increases the rate of protein-unbound free propofol in human serum

丙戊酸增加人血清中未结合蛋白质的游离丙泊酚的比率

• 发表时间: 2012
• 作者: Minako Ishii;Satoru Sakurai;Hitoshi Higuchi;Yumiko Tomoyasu;Sigeru Maeda;Takuya Miyawaki
• 通讯作者: Takuya Miyawaki

idazolam is associated with delay in recovery and agitation after ambulatory general anesthesia for dental treatment in patients with disabilities: a retrospective cohort study

咪达唑仑与残疾患者牙科治疗的门诊全身麻醉后恢复延迟和躁动有关：一项回顾性队列研究

• 发表时间: 2012
• 期刊: J Oral Maxillofac Surg
• 作者: Maeda S;Tomoyasu Y;Higuchi H;Mori T;Egusa M;Miyawaki T
• 通讯作者: Miyawaki T

Liposome-encapsulated midazolam for oral administration

口服用脂质体包裹的咪达唑仑

• 发表时间: 2011
• 期刊: J Liposome Res
• 影响因子: 4.4
• 作者: Tomoyasu Y;Yasuda T;Maeda S;Higuchi H;Miyawaki T
• 通讯作者: Miyawaki T

The influence of oral VPA on the required dose of propofol for sedation during dental treatment in patients with mental retardation: A prospective observer-blinded cohort study

• DOI: 10.1111/j.1528-1167.2011.03328.x
• 发表时间: 2012-01-01
• 期刊: EPILEPSIA
• 影响因子: 5.6
• 作者: Ishii, Minako;Higuchi, Hitoshi;Miyawaki, Takuya
• 通讯作者: Miyawaki, Takuya

Locally Injected Dexmedetomidine Induces Peripheral Vasoconstriction via Alpha-2 Adrenoceptors

局部注射右美托咪定通过 Alpha-2 肾上腺素受体诱导外周血管收缩

• 发表时间: 2013
• 作者: YABUKI;A. YAMANE;Y. TOMOYASU;H. HIGUCHI;S. MAEDA;and T. MIYAWAKI
• 通讯作者: and T. MIYAWAKI