Development of bioactive orthodontic mini-screw with nano-apatite layer

在这项研究中，我们开发了两种表面改性的钛合金，提高其生物功能活性。采用3% H2O2水热法对Ti-6Al-4V表面进行了改性。在处理后的表面观察到纳米结构的TiO2多孔网络。将TiO2钛盘浸泡在过饱和磷酸钙溶液中，形成纳米磷灰石层。我们评估了FGF2修饰表面的表面分析和生物活性。结果表明，细胞增殖和分化能力明显增强，生物功能活性明显增强。

In this study, we have developed two surface modifications of titanium alloy that improves its biofunctional activity. The surface of a Ti-6Al-4V disk was modified by applying 3% H2O2 hydrothermal treatment using an autoclave. A nanostructured porous network TiO2 was observed on the treated surface. Furthermore, the TiO2 titan disks were immersed in the supersaturated calcium phosphate solution to formed nano-apatite layer. We evaluated the surface analysis and bioactivities for FGF2 coated modified surfaces. As the results, significantly higher cell proliferation and celldifferentiation were exhibited, and enhanced biofunctional activity.