Significance of osteopontin in gingival crevicular fluid of diabetes-associated periodontitis patients.

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In the experiments of rat diabetic periodontitis model, histochemical investigation revealed that osteopontin was greatly localized in the portion of periodontal inflammatory sites, suggesting that osteopontin might be involved in the progression of severe periodontitis. The assay of gingival crevicular fluid from periodontitis patients revealed that osteopontin was not clearly detected but type-1 collagen peptide: ICTP) was detected in patients with severe periodontitis.