Study on control effect of the lifestyle-related disease through the BDNF factor by the chewing stimulation

通过DNA微阵列分析，研究了习惯咀嚼负荷的差异是否会影响与小鼠糖脂代谢相关的基因表达的可能性。在成分相同的颗粒喂养组和粉状喂养组的比较中，植入芯片的194个基因中，肥胖糖尿病小鼠腮腺中35%的mRNA水平与正常小鼠腮腺中60%的mRNA水平存在显著差异。各基因在饲喂组间的转录水平差异显著，颗粒饲喂组的信号高于粉饲喂组。

DNA microarray analyses were performed to examine a possibility whether difference in the habitual-chewing-load would affect expression of genes that linked to the glucose and lipid metabolism using mice.In a comparison between groups of pellet feeding and powdery feeding, of which components were the same, parotid gland from the obese diabetes mice showed significant difference in the mRNA level in 35% of 194 genes installed to the chip, and ones from the normal mice about 60%. Each genes which showed a significantly different transcription level between the feeding groups, signals of pellet feeding group were higher than ones of powder feeding group.