Demonstrative Study to Establish Treatment for Skin Wounds Caused by Anti-cancer Drug Leakage Based on Empirical Knowledge

在门诊化疗室工作的护士将紫杉醇（右）、泰索替尔（右）和纳威滨（右）列为抗癌药物，患者可能会报告由于这些药物从静脉渗漏而造成皮肤伤口和血管痛。护士们分享了他们的经验知识，即当发生渗漏时，舒适的冷发酵应用实际上是有效的。此外，还需要验证局部类固醇皮下注射的有效性，我们使用实验动物（大鼠）进行了研究。因此，与温暖的刺激或不使用任何刺激相比，冷刺激的应用减少了皮肤损伤，并呈现出与他们的经验知识所表明的相同的效果。局部类固醇皮下注射与纳威滨(R)显示出一定程度的抗炎作用，只有和其他抗癌药物显示出明确的有效性。

The nurses who work at outpatient chemotherapy rooms list Taxol(R), Taxotere(R), and Navelbine(R), as the anticancer drugs thatpatients are likely to report skin wounds due to their leakage out of veins, and angialgia. The nurses shared their empirical knowledge that a comfortable level of cold fomentation application is actually effective when the leakage occurs. There was also a request for verifying the effectiveness of topical steroid hypodermic injections and we conducted research using experimental animals (rats). As a result, the application of cold fomentations reduced skin injuries when compared to warm fomentations or without theapplication of any fomentation, and presented the same effect as their empirical knowledge suggested. Topical steroid hypodermic injections showed a certain level of anti-inflammatory effects with Navelbine(R), only and other anticancer drugs did show clear effectiveness.