Development of RNA aptamer against toxic Aβ oligomer

点击翻译按钮获取中文摘要

Amyloid β-protein (Aβ), a causative agent of Alzheimer’s disease, aggregates and shows neurotoxicity. It has been well documented that Aβ oligomer (toxic dimer) is mostly related to the neurotoxicity. We have demonstrated that the formation of turn structure at position 22 and 23 plays a critical role in the oligomerization of Aβ. However, it is quite difficult to synthesize Aβoligomer due to the potent ability of Aβ to aggregate. To develop RNA apatamer against toxic Aβdimer, we synthesized Aβ40 dimer, in which Ala30 was substituted with diaminopimelic used as anintermolecular linker. The development of aptamer against Aβ40 dimer is under way.