Analysis of age-related sensory organ defects using Chemical Biology

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The survival of sensory neurons is essential for the long-term maintenance of sensory function, and defects in sensory cells survival lead to the onset of age-related sensory defects such as hearing loss or retinitis pigmentosa. In this study we have shown that there seems to be a mechanism, which represses the expression of apoptotic genes, under stress signalling of Drosophila sensory organs. We expect that the mechanism for maintaining photoreceptor cells will lead to the comprehensive understanding of sensory defects, such as age-related hearing disorders.