Analysis of age-related sensory organ defects using Chemical Biology

感觉神经元的存活对于感觉功能的长期维持至关重要，而感觉细胞存活的缺陷会导致与年龄相关的感觉缺陷的发生，如听力损失或视网膜色素变性。在这项研究中，我们发现在果蝇感觉器官的应激信号下，似乎存在一种抑制细胞凋亡基因表达的机制。我们期望维持光感受器细胞的机制将导致对感觉缺陷的全面理解，例如年龄相关性听力障碍。

The survival of sensory neurons is essential for the long-term maintenance of sensory function, and defects in sensory cells survival lead to the onset of age-related sensory defects such as hearing loss or retinitis pigmentosa. In this study we have shown that there seems to be a mechanism, which represses the expression of apoptotic genes, under stress signalling of Drosophila sensory organs. We expect that the mechanism for maintaining photoreceptor cells will lead to the comprehensive understanding of sensory defects, such as age-related hearing disorders.