Are affective disorder for school-age children influenced by dietary habit and environmental chemical compounds ?

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Recently, children with learning disabilities and affective disorder are increasing.We previously reportedthat zinc benzoate, a contaminating environmentalcompound, inhibited A-type monoamine oxidase (MAOA). In this report, we investigated how zinc and zinc benzoate influenced activity of MAOA. Microarrayanalysis of brain tissues isolated from mice fed zinc, zinc benzoate or sodium benzoate diets revealed that the regulation of genes involved calcium signal transduction and neuroactive ligand-receptor interactionwere changed.