Effects of radiation exposure of adolescents on chemical carcinogenesis

青少年辐射暴露对化学致癌的影响

• 批准号: 22610026
• 负责人: AMASAKI Yoshiko
• 金额: $ 2.16万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22610026/
• 关键词: 思春期; 放射線; 胸腺リンパ腫; 複合曝露; がん; 環境; Ikaros

We clarified the combined effect of chemical carcinogen treatment with radiation exposure in adolescence, focusing on the effect of the interval between the exposures. We observed the incidence of thymic lymphoma was almost 100% when intervening interval was zero or two weeks. But it decreased significantly when the interval was four or eight weeks. The mutation spectrum of Ikaros (tumor suppressor gene) in the lymphomas was different between the different interval groups. These results suggested that the carcinogenic mechanism of combined exposures varies, depending on the timing of the exposures.

我们阐明了化学致癌物治疗与辐射暴露在青春期的综合影响，重点是曝光之间的间隔的影响。观察到间隔0 ~ 2周时胸腺淋巴瘤的发生率几乎为100%。但当间隔时间为4周或8周时，其显著降低。淋巴瘤中抑癌基因Ikaros的突变谱在不同时间组间存在差异。这些结果表明，组合暴露的致癌机制各不相同，这取决于暴露的时间。

项目成果

Molecular interaction of X-rays and N-ethyl-N-nitrosourea in thymic lymphomagenesis depends on the interval of two treatments

X射线和N-乙基-N-亚硝基脲在胸腺淋巴瘤发生中的分子相互作用取决于两次治疗的间隔

• 发表时间: 2012
• 作者: 鳥飼幸太;ほか2名;Y. Amasaki
• 通讯作者: Y. Amasaki

Molecular interaction of X-rays and N-ethyl-N-nitrosourea in thymic lymphomagenesis depends on the interval of the two treatme

X射线和N-乙基-N-亚硝基脲在胸腺淋巴瘤发生中的分子相互作用取决于两种治疗的间隔

• 发表时间: 2012
• 作者: R Tansho;Y Takada;他6名;甘崎佳子
• 通讯作者: 甘崎佳子

Effect of the interval period between exposures to ionizing radiation and N-ethyl-N-nitrosourea on the development of murine thymic lymphoma

电离辐射和N-乙基-N-亚硝基脲暴露间隔期对小鼠胸腺淋巴瘤发生的影响

• 发表时间: 2011
• 作者: 永渕功輔、高田義久;他6名;Y. Amasaki
• 通讯作者: Y. Amasaki