Effects of radiation exposure of adolescents on chemical carcinogenesis

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We clarified the combined effect of chemical carcinogen treatment with radiation exposure in adolescence, focusing on the effect of the interval between the exposures. We observed the incidence of thymic lymphoma was almost 100% when intervening interval was zero or two weeks. But it decreased significantly when the interval was four or eight weeks. The mutation spectrum of Ikaros (tumor suppressor gene) in the lymphomas was different between the different interval groups. These results suggested that the carcinogenic mechanism of combined exposures varies, depending on the timing of the exposures.