Functional analysis of a mechanical stress responsible geneFbxo32 on bone volume regulation

通过对Fbxo32基因敲除小鼠的分析，阐明了Fbxo32基因敲除小鼠骨容量调节的部分分子机制。通过小鼠尾悬吊实验后的骨形态计量学分析，发现成骨细胞中Fbxo32基因的表达与骨形成中的骨体积相关，而与骨密度无关。此外，向野生型小鼠和Fbxo32敲除小鼠施用异丙肾上腺素，确认股骨之间的形态测定值相似，表明Fbxo32不参与交感神经刺激的骨体积减少。

We clarified a part of molecular mechanisms on bone volume regulation by analyzingFbxo32 knockout mice. By bone morphometric analysis after mouse tail suspensionexperiments, it appeared that Fbxo32 gene expression in osteoblasts was associated with the bone volume but not bone density in the bone formation. Further, wild type mice and Fbxo32 knockout mice were administered isoproterenol, similar morphometric value between the femurs was recognized, indicating that Fbxo32 was not involved in a sympathetic nerve-stimulated decrease of bone volume.