Development of a nonhuman primate model of depression by serotonin deficiency

开发因血清素缺乏而导致抑郁症的非人灵长类动物模型

• 批准号: 22650087
• 负责人: NAKAMURA Katsuki
• 金额: $ 2.12万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650087/
• 关键词: 社会行動; うつ病; マーモセット

We attempted to develop a new nonhuman primate model of depression. First, cornflakes were given to marmoset monkeys because cornflakes contained less tryptophan. However, we failed to induce any symptoms in the marmosets. Second, marmosets were injected with Reserpine, which could reportedly induce symptoms of depression in humans. Reserpine induced some symptoms in marmoset monkeys similar to those of depression, such as reduction of the general activity, droopy eyelid, etc. Because of the small number of subjects, further experiments are needed.

我们试图开发一种新的非人类灵长类抑郁症模型。首先，玉米片被喂给猕猴，因为玉米片含有较少的色氨酸。然而，我们未能在绒猴身上引发任何症状。其次，给绒猴注射利血平，据报道，这可能会导致人类出现抑郁症状。利血平在猕猴身上引起了一些与抑郁症类似的症状，如一般活动减少、眼皮下垂等。由于受试者数量较少，还需要进一步的实验。