Molecular cell biomechanical analysis of novel pharmacological activity of monosaccharide

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This research project gave a new insight into the action of monosaccharide as it causes mesh-formation on cultured mouse vascular endothelial cells, a part of angiogenic response in mono layered cells. The point of action is glycan on cell surface proteins ; a treatment of cells with monosaccharide causes modification of glycans on cell surface adhesive proteins, resulting in the alteration on adhesive forces of the cell. This project has an advantage on research team as they can share the favorite field for detailed analysis ; molecular biological analyses by the team of Chiba Univ. and functional analyses by using engineering techniques by the team of Nagoya Inst. Tech. Therefore, this project becomes a first step for conducting "Molecular Cell Biomechanics" research in combination with the scientists from different fields to fulfill higher demand in scientific project.