Molecular cell biomechanical analysis of novel pharmacological activity of monosaccharide

本研究对单糖在培养的小鼠血管内皮细胞上形成网状结构的作用有了新的认识，这是单层细胞血管生成反应的一部分。作用点是细胞表面蛋白上的聚糖；用单糖处理细胞会使细胞表面粘附蛋白上的聚糖发生修饰，从而导致细胞粘附力的改变。这个项目在研究团队中有一个优势，他们可以分享自己喜欢的领域进行详细的分析；利用千叶大学团队的分子生物学分析和名古屋工业大学团队的工程技术进行功能分析。因此，该项目成为与不同领域的科学家联合开展“分子细胞生物力学”研究的第一步，以满足科学项目的更高要求。

This research project gave a new insight into the action of monosaccharide as it causes mesh-formation on cultured mouse vascular endothelial cells, a part of angiogenic response in mono layered cells. The point of action is glycan on cell surface proteins ; a treatment of cells with monosaccharide causes modification of glycans on cell surface adhesive proteins, resulting in the alteration on adhesive forces of the cell. This project has an advantage on research team as they can share the favorite field for detailed analysis ; molecular biological analyses by the team of Chiba Univ. and functional analyses by using engineering techniques by the team of Nagoya Inst. Tech. Therefore, this project becomes a first step for conducting "Molecular Cell Biomechanics" research in combination with the scientists from different fields to fulfill higher demand in scientific project.