Association of food intake and epigenetics in life-style related diseases

生活方式相关疾病中食物摄入量与表观遗传学的关联

• 批准号: 22650180
• 负责人: TAKEDA Eiji
• 金额: $ 2.12万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650180/
• 关键词: 生活習慣病; 食事; エピゲノム修飾; 胎児; 栄養過剰; 栄養不良; DNAメチル化; エピジェネティクス; 膵臓; Pdx1; 肥満; 糖尿病; カロリー制限; Insulin1

Maternal under-nutrition and over-nutrition during the intrauterine and early neonatal period have been implicated for disease risk in offspring during adulthood. The calorie restriction exhibited poor glycemic control and raised cholesterol levels, key determinants of metabolic risk, more than the high caloric group. Global DNA methylation data indicated that the high fat diet and calorie restriction may have increased and reduced gene activity in the liver methylome, respectively.

母亲在宫内和新生儿早期的营养不足和过度营养与成年后的后代疾病风险有关。与高热量组相比，限制卡路里摄入显示出血糖控制不佳，并提高了胆固醇水平，而胆固醇水平是代谢风险的关键决定因素。全球DNA甲基化数据表明，高脂肪饮食和卡路里限制可能分别增加和降低了肝脏甲基组中的基因活性。

项目成果

がん栄養療法ガイドブック第2版

癌症营养治疗指南第二版

• 发表时间: 2011
• 作者: N.Harada;S.Iwaki;M.Tonoike;武田英二
• 通讯作者: 武田英二