Association of food intake and epigenetics in life-style related diseases
Association of food intake and epigenetics in life-style related diseases
批准号:
22650180
负责人:
TAKEDA Eiji
金额:
$2.12万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Maternal under-nutrition and over-nutrition during the intrauterine and early neonatal period have been implicated for disease risk in offspring during adulthood. The calorie restriction exhibited poor glycemic control and raised cholesterol levels, key determinants of metabolic risk, more than the high caloric group. Global DNA methylation data indicated that the high fat diet and calorie restriction may have increased and reduced gene activity in the liver methylome, respectively.
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DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[N.Harada, S.Iwaki, M.Tonoike, 武田英二]
通讯作者:
武田英二
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