Development of a Simulation Technique for Gene/Cancer Therapy Using Nano/Micro Bubbles

本研究的目的是开发一种利用气泡塌陷进行基因治疗的技术。对声学脂质体在压力变化下的运动进行了实验研究，建立了声学脂质体的气泡模型。使用边界元法或虚拟流体法模拟组织表面附近气泡的破裂。还开发了一种模拟技术，用于使用气泡崩溃的治疗分子的运输。结果表明，由于气泡表面磷脂层的减少，气泡运动受表面张力的影响很大。组织边界速度与由于气泡破裂而在组织处的脉冲相关。利用液体射流产生的涡流伴随着气泡的崩溃是有效的在传输的分子。

This study is aimed to develop a technique for gene therapy using bubble collapse. The motion of acoustic liposomes under pressure change is investigated experimentally and a bubble model for acoustic liposomes is developed. The collapse of a bubble near a tissue surface is simulated using the boundary element method or the ghost fluid method. A simulation technique is also developed for the transport of therapeutic molecules using bubble collapse. It is shown that the bubble motion is much affected by the variation of surface tension due to the reduction of phospholipid layers on the bubble surface. The tissue boundary velocity is correlated to the impulse at the tissue due to bubble collapse. The usage of vortex flows generated by the liquid jet accompanied with bubble collapse is effective in transporting the molecules.