Development of a Simulation Technique for Gene/Cancer Therapy Using Nano/Micro Bubbles

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This study is aimed to develop a technique for gene therapy using bubble collapse. The motion of acoustic liposomes under pressure change is investigated experimentally and a bubble model for acoustic liposomes is developed. The collapse of a bubble near a tissue surface is simulated using the boundary element method or the ghost fluid method. A simulation technique is also developed for the transport of therapeutic molecules using bubble collapse. It is shown that the bubble motion is much affected by the variation of surface tension due to the reduction of phospholipid layers on the bubble surface. The tissue boundary velocity is correlated to the impulse at the tissue due to bubble collapse. The usage of vortex flows generated by the liquid jet accompanied with bubble collapse is effective in transporting the molecules.