Cruciate injury model and cruciate regeneration with MSC by using of BPR system in micro-mini pig.

利用 BPR 系统建立微型猪十字韧带损伤模型及 MSC 再生十字韧带。

• 批准号: 22658100
• 负责人: FUJIKI Makoto
• 金额: $ 2.22万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22658100/
• 关键词: 半月板再生; 半月板; 再生; 立体構造; マイクロミニピッグ; 膝OAモデル

The tissue regeneration was researched by using micro mini-pig(MMP) with the mesenchymal system cell derived from subcutaneous adipose tissue for meniscus injury model. It was confirmed that the preparation of plug for transplantation with mesenchymal cells derived from subcutaneous fat is possible. However, it was not possible to confirm meniscus regeneration by being not able to maintain the nature of the transplant spheroid for partial deficit model of the MMP. In meniscus and osteochondral defect model without arthrotomy, the effectiveness of knee osteoarthritis as a model was suggested.

采用微型猪皮下脂肪组织来源的间充质干细胞建立半月板损伤模型，研究其对半月板损伤的修复作用。证实了用来自皮下脂肪的间充质细胞制备用于移植的栓塞是可能的。然而，对于MMP的部分缺陷模型，不能通过不能保持移植球体的性质来确认半月板再生。在半月板和骨软骨缺损的非关节切开模型，膝关节骨关节炎作为一种模型的有效性。