Photochromic DNA Binding Ligands for B and Z-DNA Interconversion

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This study has aimed at the development of photochromic DNA binding ligands for B Z-DNA interconversion. It has been shown from SPR and ITC measurements that the P[ 5] helicene ligand has higher affinity to B-DNA and the M-[ 5] helicene ligand dose to Z-DNA. The bisary ligand with the azobenzene unit and the naphthalene unit induced B-Z transition, and Z-DNA was returned to B-DNA by UV irradiation. Thus, this study has shown the first example of the photochromic ligand for B-Z conversion.