Mechanisms of bone metastasis of tumor cells by endothelial-mesenchymal transition of vascular endothelial cells.

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We clarified that human synovial sarcoma and oral cancer cells induced vascular endothelial cells into the tumors by Src-dependent VEGF production and oral environment specific induction of RANKL, respectively. In addition, using in vitro 3D culture system we have established, synovial sarcoma cells aggressively invaded into the tubes formed by HUVECs, leading to the morphological alterations like endothelialmesenchymal transition in HUVECs, resulted in the aberrant tube formation combined with synovial sarcoma cells.