Development of a new drug delivery system using micro bubbles

利用微泡开发新型药物输送系统

• 批准号: 22659220
• 负责人: KAMINOU Toshio
• 金额: $ 1.26万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659220/
• 关键词: 動注化学療法; 抗癌剤; ドラッグデリバリーシステム; 悪性腫瘍; 超音波造影剤; マイクロバブル

As a chemotherapy for hepatocellular carcinoma, hepatic arterial infusion chemotherapy has been mainly performed. But no effective drug delivery system for the treatment of hepatocellular carcinoma has been developed. We examined usefulness of micro-bubbles formed at the surface of ultrasonographic contrast media as an intra-arterial drug delivery system. The affinity of micro-bubbles and anti-cancer drugs (CDDP, MMC, epi-ADR) was defective. Micro-bubbles released powder of anticancer drugs within a short time. Micro-bubbles made by whipping methods were not to be an effective drug delivery system.

肝动脉灌注化疗作为肝癌的一种化疗方法，一直以来主要采用。但是目前还没有开发出有效的治疗肝癌的药物释放系统。我们研究了在超声造影剂表面形成的微泡作为动脉内药物输送系统的有用性。微泡与抗癌药物（顺铂、丝裂霉素、表阿霉素）的亲和性较差。微泡在短时间内释放抗癌药物粉末。通过搅打方法制备的微泡不是有效的药物递送系统。