Development of a new drug delivery system using micro bubbles

肝动脉插管化疗作为肝细胞癌的一种化疗手段，已成为治疗肝癌的主要手段。但目前尚无治疗肝细胞癌的有效给药系统。我们研究了超声造影剂表面形成的微泡作为动脉内给药系统的有用性。微泡与抗癌药物(CDDP、MMC、EPI-ADR)的亲和力存在缺陷。微泡在短时间内释放抗癌药物粉末。搅拌法制成的微泡并不是一种有效的药物释放系统。

As a chemotherapy for hepatocellular carcinoma, hepatic arterial infusion chemotherapy has been mainly performed. But no effective drug delivery system for the treatment of hepatocellular carcinoma has been developed. We examined usefulness of micro-bubbles formed at the surface of ultrasonographic contrast media as an intra-arterial drug delivery system. The affinity of micro-bubbles and anti-cancer drugs (CDDP, MMC, epi-ADR) was defective. Micro-bubbles released powder of anticancer drugs within a short time. Micro-bubbles made by whipping methods were not to be an effective drug delivery system.