Discovery omics for molecular targeted portal vein embolization and the efficiency of enlargement of the liver

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Portal vein Branch Ligation model was raised, we examined the liver enlargement rate of non-ligation lobe, and expressions of mRNA and proteins of the target molecule of Nrf2 in Nrf2 knockout mouse, liver specific Keap1 knockout mouse, and wild type. In the wild type showed enlargement of the liver in the non-ligation lobe significant compared to Nrf2 knockout mice. In addition, expression of Nqo1 in non-ligation lobe was significantly increased compared to the ligation lobe.