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Establishment of the dental pulp stem cell using a low molecular weight compound for tooth regeneration

Establishment of the dental pulp stem cell using a low molecular weight compound for tooth regeneration
使用低分子量化合物建立牙髓干细胞用于牙齿再生
批准号:
22659373
负责人:
IWAMOTO Tsutomu
金额:
$2.12万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

IWAMOTO Tsutomu的其他基金

相关文献

中文摘要
翻译
我们发现糖原合成酶激酶3 (GSK3)抑制剂BIO可诱导小鼠牙乳头源性间充质(mDP)细胞形态学改变,并促进Nanog mRNA的表达,而Nanog mRNA被认为是多能性的关键基因。BIO处理的mDP细胞在成骨分化培养基中培养后,成骨细胞制造基因的表达和碱性磷酸酶活性逐渐增加。
英文摘要
We found that BIO, a glycogen synthase kinase-3 (GSK3) inhibitor, induced changes in cell morphology, and promoted the expression of Nanog mRNA, considered the key gene to pluripotency, in mouse dental papilla derived mesenchymal (mDP) cells. When the BIO treated mDP cells were cultured in osteogenic differentiation medium, the expression of osteoblast maker genes and alkaline phosphatase activity were progressively increased.
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会议论文
Expressions and Functions of Neurotrophic Factors in Tooth Development
神经营养因子在牙齿发育中的表达和功能
DOI: --
发表时间: 2011
期刊: J Oral Biosci
影响因子: 2.4
作者: [Iwamoto T, Yamada A, Arakaki M, Sugawara Y, Ono M, Futaki M, Yoshizaki K, Fukumoto E, Nakamura T, Fukumoto S]
通讯作者: Fukumoto S
Epithelial-mesenchymal interaction reduces inhibitory effects of fluoride on proliferation and enamel matrix expression in dental epithelial cells
上皮-间质相互作用降低氟化物对牙上皮细胞增殖和牙釉质基质表达的抑制作用
DOI: --
发表时间: 2012
期刊: Pediatric Dental Journal
影响因子: 0.8
作者: [Yamada A, Iwamoto T, Fukumoto E, Arakaki M, Miyamoto R, Sugawara Y, Komatsu H, Nakamura T, Fukumoto S]
通讯作者: Fukumoto S
歯および軟細胞におけるPannexin3の役割
Pannexin3 在牙齿和软细胞中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [岩本勉, 福本敏]
通讯作者: 福本敏
DOI: 10.1016/j.archoralbio.2010.03.011
发表时间: 2010-06
期刊: Archives of oral biology
影响因子: 3
作者: [N. Wu;Tsutomu Iwamoto;Yu Sugawara;Masaharu Futaki;K. Yoshizaki;Shinya Yamamoto;A. Yamada;Takashi Nakamura;K. Nonaka;S. Fukumoto]
通讯作者: N. Wu;Tsutomu Iwamoto;Yu Sugawara;Masaharu Futaki;K. Yoshizaki;Shinya Yamamoto;A. Yamada;Takashi Nakamura;K. Nonaka;S. Fukumoto
共 24 条
    Cell fate determination of mesenchymal stem cells by extracellular mechanical stress
    • 批准号:
      17H04414
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2017
    • 负责人:
      IWAMOTO Tsutomu
    • 依托单位:
    role of preodontoblast in tooth development
    • 批准号:
      26293435
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.57万
    • 财政年份:
      2014
    • 负责人:
      IWAMOTO Tsutomu
    • 依托单位:
    Epithelial mesenchymal interaction mediated by exosomes in tooth development
    • 批准号:
      25670869
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      IWAMOTO Tsutomu
    • 依托单位:
    Roles of gap junction proteins in odontoblast differentiation