Investigation of a biomarker index on exercise effects with breast cancer survivors who received chemotherapy

接受化疗的乳腺癌幸存者运动效果生物标志物指数的调查

• 批准号: 22659404
• 负责人: TONOSAKI Akiko
• 金额: $ 2.16万
• 依托单位: Research Institute, International Medical Center of Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659404/
• 关键词: がん; バイオマーカー; インスリン抵抗性; 身体活動量; 身体組成; 抑うつ; 看護学; 運動療法; 認知機能

Sedentary behavior is positively associated with an increased risk of obesity and metabolic syndrome. It is suggested that sedentary time has an association with insulin resistance. The breast cancer survivors who received chemotherapy had a tendency towards a sedentary life-style. The purpose of this pilot study was to assess the effect of the amount of time of physical activity intensity levels on insulin resistance, weight gain and body composition among breast cancer survivors who received chemotherapy. Insulin resistance was measured through the Homeostasis Model Assessment score (HOMA-R). The rate of weight gain was strongly negatively correlated with the average amount of time with more than 3.0 METs (metabolic equivalent). We are continuing to collect data to increase the sample size.

久坐行为与肥胖和代谢综合征的风险增加呈正相关。这表明久坐与胰岛素抵抗有关。接受化疗的乳腺癌幸存者倾向于久坐不动的生活方式。这项初步研究的目的是评估接受化疗的乳腺癌幸存者的身体活动强度水平对胰岛素抵抗、体重增加和身体成分的影响。通过稳态模型评估评分（HOMA-R）测量胰岛素抵抗。体重增加率与平均代谢当量大于3.0的时间呈强烈负相关。我们正在继续收集数据以增加样本量。

项目成果

Sedentary lifestyle and physical activity in patients receiving adjuvant chemotherapy

接受辅助化疗患者的久坐生活方式和体力活动

• 发表时间: 2013
• 作者: 山下知美;法橋尚宏;小林京子;石垣和子;Akiko Tonosaki
• 通讯作者: Akiko Tonosaki

がんサバイバーの身体活力の回復をめざすプログラム

旨在恢复癌症幸存者身体活力的计划

Impact of daily activity and physical condition on QOL of women receiving cancer chemotherapy

日常活动和身体状况对接受癌症化疗的女性生活质量的影响

• 发表时间: 2011
• 作者: 片倉直子;石垣和子;Akiko Tonosaki
• 通讯作者: Akiko Tonosaki