Study on physiological function of a novel food intake-regulatory hypothalamic gene and its transcript

最近，我们在鸟类和哺乳动物的大脑中发现了一个新的下丘脑基因，它编码一种神经肽。由于mRNA在不同能量状态（如禁食和肥胖）下的表达变化，我们预测该新基因可能与能量稳态，特别是食物摄入有关。在这项研究中，我们研究了以下分析，成熟内源性肽的鉴定，对食物摄入的影响，与已知物质的组织学关系，外周物质的调节机制，以及系统发育分析。

Recently, we have identified a novel hypothalamic gene which encodes a neuropeptide in the avian and mammalian brains. As the mRNA expression was changed during different energy states such as fasting and obesity, we predict that this novel gene may be involved in the energy homeostasis, especially food intake. In this study, we investigated the following analyses, identification of mature endogenous peptide, effect on food intake, histological relationships with known substances, regulatory mechanisms by peripheral substances, and phylogenetic analysis.