Molecular pathophysiology of autism-like behavior in glutamate transporter knockout mice.

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Compulsive-repetitive behaviors are common core symptom that are shared between autism spectrum disorders and obsessive-compulsive spectrum disorders. The underlying pathogenic mechanisms of compulsive-repetitive behaviors are largely unknown. Here we show glutamate transporter conditional knockout mice exhibit compulsive-repetitive behaviors due to increased glutamate neural transmission. These findings demonstrate glutamatergic hyperactivity is important for pathogenesis of compulsive-repetitive behaviors.