GnIH regulates social behavior through midbrain dopaminergic neurons.

腹侧被盖区(VTA)含有在调节动机行为、成瘾和奖赏方面很重要的多巴胺神经元。在这里，我们显示VTA多巴胺神经元表达GnIH受体mRNA，并接受含有促性腺激素抑制激素(GnIH)的突触输入。此外，我们检测了男性大脑中GnIH神经元活性的变化，这些变化发生在对女性的看法和与女性的性行为互动之后。女性的存在似乎导致了男性间脑GnIH基因表达水平的变化。这些数据支持中枢GnIH的新角色，并可能对性动机的调节产生影响

The ventral tegmental area(VTA) contains dopamine neurons that are important in modulating motivated behavior, addiction, and reward. Here, we show that VTA dopamine neurons express GnIH receptor mRNA and receive synaptic input that contains gonadotropin-inhibitory hormone(GnIH). Furthermore, we examined changes in the activity of GnIH neurons in the brain of male following a view of and sexual interaction with a female. The presence of female seems to result in a change in diencephalic GnIH mRNA levels of male. These data support a new role for central GnIH with possible implications for regulation of sexual motivation