GnIH regulates social behavior through midbrain dopaminergic neurons.

腹侧被盖区（VTA）包含多巴胺神经元，在调节动机行为、成瘾和奖励中起重要作用。本研究表明，VTA多巴胺神经元表达GnIH受体mRNA，并接受含有促性腺激素抑制激素（GnIH）的突触输入。此外，我们研究了男性在与女性发生性行为后大脑中GnIH神经元活动的变化。雌性的存在似乎导致雄性间脑GnIH mRNA水平的变化。这些数据支持中央GnIH的新角色，可能对性动机的调节有影响

The ventral tegmental area(VTA) contains dopamine neurons that are important in modulating motivated behavior, addiction, and reward. Here, we show that VTA dopamine neurons express GnIH receptor mRNA and receive synaptic input that contains gonadotropin-inhibitory hormone(GnIH). Furthermore, we examined changes in the activity of GnIH neurons in the brain of male following a view of and sexual interaction with a female. The presence of female seems to result in a change in diencephalic GnIH mRNA levels of male. These data support a new role for central GnIH with possible implications for regulation of sexual motivation