Development of MR microscope for organogenesis research

我们研制了一台14.1T强磁场磁共振显微镜。我们在20 μm等体素三维可视化化学固定的青鳉，其中施加最大4.0 T/m的场梯度。比较p53抑癌基因突变型青鳉与野生型青鳉的3D MR图像，获得内脏器官的差异。除此之外，我们还分析了定量磁化率图中的数字化效应，这给了我们一个组织铁含量图，可用于检测帕金森病患者大脑中的局部铁积累。

We developed a magnetic resonance microscope by using high magnetic field of 14.1 T. We visualized chemically-fixed medaka in 20 μm isovoxel three dimensionally, where field gradients of 4.0 T/m at maximum were applied. Comparing 3D MRimages of p53 cancer suppressor gene mutant medaka with those of wild type medaka, differences in internal organs were obtained. In addition to that, we analyzed digitized effects in quantitative susceptibility mapping, which gave us a tissue iron contentmap and could be used for detecting local iron accumulation in a brain of a Parkinson’s disease patient.