Development of MR microscope for organogenesis research

利用14.1 T的强磁场，建立了一种磁共振显微镜，在20 μm的异体素上对化学固定的medaka进行了三维可视化，最大磁场梯度为4.0 T/m。将p53抑癌基因突变体medaka与野生型medaka的3D图像进行比较，得到了内脏器官的差异。除此之外，我们还分析了定量易感性制图中的数字化效应，这给了我们一个组织铁含量图，可以用来检测帕金森病患者大脑中的局部铁积累。

We developed a magnetic resonance microscope by using high magnetic field of 14.1 T. We visualized chemically-fixed medaka in 20 μm isovoxel three dimensionally, where field gradients of 4.0 T/m at maximum were applied. Comparing 3D MRimages of p53 cancer suppressor gene mutant medaka with those of wild type medaka, differences in internal organs were obtained. In addition to that, we analyzed digitized effects in quantitative susceptibility mapping, which gave us a tissue iron contentmap and could be used for detecting local iron accumulation in a brain of a Parkinson’s disease patient.