Development of Au-Ag nanorods for application of hyperthermic treatment

纳米技术是各个领域的有用工具。特别是，纳米材料在诊断、成像工具和治疗工具的应用中具有优势。金纳米材料，即金胶体和金纳米棒，是生物技术和肿瘤治疗的重要成像工具。我们研究了生物和化学功能材料的高分子合成，并开发了新的分散剂来稳定金纳米颗粒。以吡啶和聚乙二醇（PEG）为抗蛋白质吸附侧链制备的PEG-g-Py接枝共聚物作为分散剂稳定金纳米棒。此外，金纳米棒具有光热转换的潜力。我们开发了银薄层涂覆的金纳米棒（PEG-g-Py涂覆的金-银纳米棒）以增加用于癌症光热治疗的光热转换效率。我们研究了PEG-g-Py包覆金-银纳米棒的新材料表征。我们证实了PEG-g-Py包覆的金银纳米棒可以应用于癌症光热治疗。

Nanotechnology is useful tools for various fields. In particular, nanomaterials have advantage in application of diagnostic, imaging tools and therapeutic tools. Gold nanomaterials, gold colloid and gold nanorods, now were focused on imaging tool of biotechnology and cancer therapy. We have researched polymer synthesis of bio-and chemical-functional materials and developed new dispersing agent to stabilize gold nanoparticles. This dispersing agent which PEG-g-Py Graft copolymer made from pyridine and poly(ethylene glycol)(PEG) as protein adsorption-resistant pendant chains was used to stabilize gold nanorods. Moreover gold nanorods have potential of photothermal conversion property. We developed Silver thin layer coated gold nanorods(PEG-g-Py coated Gold-Silver nanorods) to increase the photothermal conversion efficiency for cancer photothermal therapy. We researched new materials characterization of PEG-g-Py coated Gold-Silver nanorods. We confirmed that PEG-g-Py coated Gold-Silver nanordos could apply cancer photothermal therapy.