Development of highly-selective antimicrobial agents based on the concept of polymer architecture

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In this study, we developed novel antimicrobial polymers inspired by the features of natural host-defense peptides. Membrane perturbation, which is utilized in this study, is promising approach to achieve antimicrobial activity with minimized production of drug-resistant bacteria. It was clarified that we can control interaction of the polymers with cell membranes by proper tuning of polymer structure. As a result, antimicrobial activity and toxicity to mammalian cells can be tuned by changing polymer structure.