Preparation and characterization of polyion complex nanoparticles using hydrophobic interaction

利用阳离子聚氨基酸和阴离子疏水修饰聚合物之间的静电和疏水相互作用，制备了由阳离子聚氨基酸和阴离子疏水修饰聚合物组成的聚离子配合物（PIC）纳米颗粒。制备的PIC纳米颗粒在生理条件下表现出高的长时间稳定性。PIC纳米颗粒稳定性的提高是由于在纳米颗粒的核心形成了疏水结构域。此外，还证实了PIC纳米颗粒作为蛋白质载体的功能。

Polyion complex(PIC) nanoparticles composed of anionic hydrophobically modified and cationic poly(amino acid) were prepared using electrostatic and hydrophobic interactions between the two polymers. The prepared PIC nanoparticles showed high stability for a prolonged period of time under physiological conditions. The improved stability of the PIC nanoparticles was attributed to the formation of hydrophobic domains in the core of the nanoparticles. Moreover, the function of the PIC nanoparticles as a protein carrier was demonstrated.