The effect on vascular endothelial function by physical stimuli and the differences in the influence by lifestyle

物理刺激对血管内皮功能的影响及生活方式影响的差异

• 批准号: 22700553
• 负责人: NOGUCHI Masahiro
• 金额: $ 2.08万
• 依托单位: Kinjo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700553/
• 关键词: 理学療法学; 血管内皮機能; 物理療法; 動脈硬化; 喫煙; 身体活動; 理学療法

The purpose of this study was to determine whether thermal or cold stimuli for peripheral vessel have an influence on endothelium function. The participants were 30 healthy men(20-21 years old, smoker 15 men and non-smoker 15 men). The smoking group and non-smoking group were compared, and RHI values of baseline, after thermal stimulus, and after cold stimulus in each group were compared. Significant difference was observed between smoking and non-smoking group with RHI(p<0.01). There was no significant difference in the comparison of RHI between baseline, after thermal stimulus, and after cold stimulus. This suggests that even if younger and short smoking duration, the chemical damage by smoking exert influence on vascular dilatation function derived from vascular endothelium.

本研究的目的是确定外周血管的热或冷刺激是否对内皮功能有影响。参与者是30名健康男性（20-21岁，吸烟者15名男性和非吸烟者15名男性）。比较吸烟组和非吸烟组的RHI值，并比较各组基线、热刺激后和冷刺激后的RHI值。吸烟组与非吸烟组的RHI差异有统计学意义（p<0.01）。基线、热刺激后和冷刺激后的RHI比较无显著差异。这表明，即使是年轻人和吸烟时间较短的人，吸烟造成的化学损伤也会影响来自血管内皮的血管扩张功能。