An experimental study on the development of new therapy for treatment of diabetes mellitus by using the combination of electrical stimulation and heat-stress

点击翻译按钮获取中文摘要

The aim of this study was to investigate the effects of therapeutic heat-stress before electrical stimulation(ES) on improvement of insulin resistance. In vitro experiments by using cultured muscle cells(C2C12 myotubes), both ES and heat-stress increased insulin-stimulated glucose uptake, but the effects were not additive. In vivo experiments by using high-fat diet-induced insulin-resistant rats, the daily application of ES improved insulin responses and increased heat shock protein(HSP) 72 and HSP27 expression in the rectus femoris muscle. These results suggest that the daily application of ES can improve insulin sensitivity, and this mechanism is related to the expression of HSPs in myocytes.