Research of the pathogenesis of chronic musculoskeletal pain-Behavioral and histological study of postnatal development factor-

我们建立了一个肌肉骨骼慢性疼痛模型（LH模型）。在该模型中，对成年大鼠的处理产生了长期持续的疼痛行为，而对年轻大鼠的处理没有产生慢性疼痛行为。组织学上，损伤的肌肉组织几乎在同一时间内恢复。这意味着慢性疼痛的发生可能与肌肉恢复以外的疼痛通路中某些不同于成人的因素有关。

We developed a musculoskeletal chronic pain model(LH model). In this model, the treatment to adult rats produced long-persisting pain behaviors, on the contrary, the treatment to young rats did not develop chronic pain behaviors. Histologically, damaged muscle tissues almost recovered in same time course with adult treated-rats and young treated-rats. These imply the possibility that some factors in pain pathway different from adult except for muscle recovery will be concerned in development of chronic pain.