Research for the regulation of voluntary exercise and energy metabolism by appetite-regulating factors

食欲调节因子对自主运动和能量代谢的调节研究

• 批准号: 22700693
• 负责人: MAWATARI Kazuaki
• 金额: $ 2.5万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700693/
• 关键词: 自発運動; 摂食調節因子; Ghrelin; 内臓脂肪; 肥満

We established a new animal model called SPORTS(Spontaneously-Running Tokushima-Shikoku) rats, which show high voluntary wheel running and low level of plasma total Ghrelin. The aim of this study was to investigate the in vivo effect of Ghrelin and Obestatin, which are appetite-regulating factors generated from prepro-Ghrelin, on voluntary wheel running and energy metabolism using the SPORTS animal model. We divided SPORTS rats into two groups, which were intramuscularly administrated Saline, Ghrelin, or Ghrelin+ Obestatin for six days(100. g/ kg BW/ day). Voluntary wheel running was significantly decreased in Ghrelin groups. Food intake, body weight, and abdominal visceral fat were significantly increased in Ghrelin groups. Obestatin suppressed Ghrelin-induced food intake, body weight, and abdominal visceral fat gains, but did not have any effect on voluntary wheel running. Our results suggest that Ghrelin and Obestatin may exert different pathway on the voluntary exercise or appetite. Some appetite-regulating factors may regulate voluntary exercise or energy metabolism.

我们建立了一种新的动物模型，称为运动(自发跑步德岛-四国)大鼠，它表现出高自愿车轮跑和低水平的血浆总生长激素水平。本研究的目的是利用运动动物模型，研究由Ghrelin前体产生的食欲调节因子--Ghrelin和OBest atin对小鼠自主跑轮和能量代谢的影响。我们将运动大鼠分为两组，分别肌肉注射生理盐水、Ghrelin或Ghrelin+奥斯汀6天(100。G/kg体重/天)。Ghrelin组的自主车轮运行显著减少。Ghrelin组的食物摄入量、体重和腹部内脏脂肪显著增加。奥斯汀抑制了Ghrelin诱导的食物摄入量、体重和腹部内脏脂肪增加，但对自愿车轮运行没有任何影响。我们的结果提示，Ghrelin和OBest atin可能对自愿运动或食欲产生不同的作用途径。一些食欲调节因子可能会调节自愿运动或能量代谢。

项目成果

栄養科学シリーズNEXT「応用栄養学」(第3版)

营养科学系列NEXT《应用营养》（第三版）

• 发表时间: 2012
• 作者: 中坊幸弘;木戸康博;馬渡一諭(他24名)
• 通讯作者: 馬渡一諭(他24名)

栄養教育論演習

营养教育理论研讨会

• 发表时间: 2012
• 作者: 志岐歩美;北原勉;吉村嘉代;深野陽子;渡辺啓子;中野修治;森山耕成;饗場直美
• 通讯作者: 饗場直美

β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model, SPORTS

• DOI: 10.1038/oby.2009.145
• 发表时间: 2010-01-01
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Hattori, Atsushi;Mawatari, Kazuaki;Nakaya, Yutaka
• 通讯作者: Nakaya, Yutaka

自発運動制御におけるGhrelinの役割

生长素释放肽在运动控制中的作用

• 发表时间: 2011
• 期刊: 肥満研究
• 作者: Hiroko Furukawa;Kazuaki Mawatari;Kei Koyama;Sonoko Yasui;Ran Morizumi;Takaaki Shimohata;Nagakatsu Harada;Akira Takahashi;Yutaka Nakaya;馬渡一諭
• 通讯作者: 馬渡一諭

栄養科学シリーズNEXT応用栄養学第3版

营养科学系列NEXT应用营养学第3版

• 发表时间: 2012
• 作者: 岡崎光子;饗場直美;馬渡一諭(他13名);馬渡一諭
• 通讯作者: 馬渡一諭