Development of function and elucidation of mechanism on the skin by oral conjugated linolenic acid

口服共轭亚麻酸对皮肤的功能开发及作用机制的阐明

• 批准号: 22700751
• 负责人: OIKAWA Daichi
• 金额: $ 2.58万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700751/
• 关键词: 共役脂肪酸; 共役リノレン酸; 皮下脂肪; 抗肥満; 坑肥満

The aim of the present study was to examine the inhibiting function of skinfold accumulation by oral conjugated linolenic acid. The conjugated linolenic acid was made from gamma-linolenic acid with the method of alkali-isorization. Rats were freely given conjugated linolenic acid for four weeks. Skin lipids(total lipid, triacylglycerol, total cholesterol, free fatty acid and free cholesterol) were determined. As a result, anti-obesity of the skin by oral conjugated linolenic acid in this study were not remarkably found.

本研究旨在探讨口服共轭亚麻酸对皮肤褶积的抑制作用。以-亚麻酸为原料，采用碱异构化法制备共轭亚麻酸。大鼠自由给予共轭亚麻酸4周。测定皮肤脂质（总脂、甘油三酯、总胆固醇、游离脂肪酸和游离胆固醇）。因此，在本研究中，口服共轭亚麻酸对皮肤的抗肥胖作用没有显著的发现。

项目成果

Functions of CLA and ARA for Prevention of CCl_4-Induced Fatty Liver in Mice.

CLA和ARA预防CCl_4诱导的小鼠脂肪肝的作用。

• 发表时间: 2010
• 期刊: Journal of Animal and Veterinary Advances
• 作者: 大無田恵美;近江雅代;熊谷奈々;藤田守;近江雅代;飯島陽子;飯島陽子;飯島陽子;Daichi Oikawa. Yoriko Akimoto. Yurika Mizobe. Shoichiro Tsuyama. Mitsuhiro Furuse.
• 通讯作者: Daichi Oikawa. Yoriko Akimoto. Yurika Mizobe. Shoichiro Tsuyama. Mitsuhiro Furuse.