The effect of Notch signaling on malignant mesothelioma cell growth and survival interval in an implant animal model of malignant mesothelioma

Notch信号对恶性间皮瘤移植动物模型中恶性间皮瘤细胞生长和生存期的影响

• 批准号: 22700912
• 负责人: YAMANDA Shinsuke
• 金额: $ 1.66万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700912/
• 关键词: 分子標記治療; ヒト悪性中皮腫; 悪性中皮腫; Notch シグナル; Delta-like 4; SCID マウス; 細胞周期; アポトーシス; Notchシグナル; SCIDマウス

In vitro, Delta-like 4-selective neutralizing antibody treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines, which was accompanied by an increase in phosphor-p53 levels. These effects partly involved induction of growth arrest to MM cells. In vivo, treatments with Delta-like 4-selective neutralizing antibody andγ-secretase inhibitor (an inhibition of Notch signaling)not significantly decreased the growth rate of MM. Finally, Delta-like 4-selective neutralizing antibody treatment also not significantly extended survival interval in an implant animal model of MM.

在体外，Delta样4-选择性中和抗体显著抑制恶性间皮瘤(MM)细胞的增殖率，并伴随着P53蛋白表达水平的升高。这些作用部分涉及诱导多发性骨髓瘤细胞生长停滞。在体内，Delta样4选择性中和抗体和γ分泌酶抑制剂(一种Notch信号的抑制)处理并没有显著降低MM的生长速度。最后，Delta样4选择性中和抗体处理也没有显著延长MM移植动物模型的生存时间。

项目成果

Adiponectin pathway attenuates malignant mesothelioma cell growth.

• DOI: 10.1165/rcmb.2011-0068oc
• 发表时间: 2012-12
• 期刊: American journal of respiratory cell and molecular biology
• 影响因子: 6.4
• 作者: K. Niu;M. Asada;Tatsuma Okazaki;S. Yamanda;T. Ebihara;Hui Guo;Dongyin Zhang;R. Nagatomi;H. Arai;M. Kohzuki;S. Ebihara

AMP活性化プロテインキナーゼ活性化と悪性中皮腫

AMP 激活蛋白激酶激活与恶性间皮瘤

• 发表时间: 2010
• 作者: 牛凱軍;海老原覚;浅田成紀;矢満田慎介;岡崎達馬;荒井啓行;永富良一
• 通讯作者: 永富良一