The effect of Notch signaling on malignant mesothelioma cell growth and survival interval in an implant animal model of malignant mesothelioma

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In vitro, Delta-like 4-selective neutralizing antibody treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines, which was accompanied by an increase in phosphor-p53 levels. These effects partly involved induction of growth arrest to MM cells. In vivo, treatments with Delta-like 4-selective neutralizing antibody andγ-secretase inhibitor (an inhibition of Notch signaling)not significantly decreased the growth rate of MM. Finally, Delta-like 4-selective neutralizing antibody treatment also not significantly extended survival interval in an implant animal model of MM.