Approach for prevention of metastasis of small cell lung cancer by targeting a specific splicing isoform of CADM1

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Small cell lung cancer(SCLC) is one of the most malignant cancers that metastasize to the distal organs even in its early stages. We examined the molecular mechanism underlying the malignant growth and metastasis of SCLC to identify candidate molecules targeting SCLC. The exogenous expression of CADM1 enhanced tumorigenicity of SCLC cells in nude mice, suggesting that the expression of CADM1 promotes malignant growth and metastasis of SCLC. Moreover, we found that PI3K and its downstream molecules may play roles in the malignant signaling mediated by CADM1 in SCLC.