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Analysis of genome-wide DNA methylation profiles of the brain in mice exposed to diesel exhaust during fetal period.

Analysis of genome-wide DNA methylation profiles of the brain in mice exposed to diesel exhaust during fetal period.
胎儿期暴露于柴油废气的小鼠大脑全基因组 DNA 甲基化谱分析。
批准号:
22710067
负责人:
TACHIBANA Ken
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Diesel exhaust(DE) was exposed to pregnant mice and genomic DNA was obtained from offspring. Subsequently, genome-wide DNA methylation analysis was performed. The results indicated that prenatal DE exposure disrupts the construction of DNA methylation pattern in the brain of offspring. It is also suggested that disrupted DNA methylation pattern is sustained during growth. Our findings provide the important information to clarify the effects and mechanisms of functional impairment of the brain induced by prenatal DE exposure.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [高柳皓平, 立花研, 秋本純芽, 新海雄介, 武田健]
通讯作者: 武田健
DOI: 10.1002/stem.753
发表时间: 2011-12-01
期刊: STEM CELLS
影响因子: 5.2
作者: [Sato, Atsushi, Sunayama, Jun, Kitanaka, Chifumi]
通讯作者: Kitanaka, Chifumi
DOI: 10.1002/stem.696
发表时间: 2011-09-01
期刊: STEM CELLS
影响因子: 5.2
作者: [Sunayama, Jun, Sato, Atsushi, Kitanaka, Chifumi]
通讯作者: Kitanaka, Chifumi
Prenatal diesel exhaust exposure disrupt the DNA methylation profile and the function of neural stem cells in the brain of mouse
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