Analysis of genome-wide DNA methylation profiles of the brain in mice exposed to diesel exhaust during fetal period.

胎儿期暴露于柴油废气的小鼠大脑全基因组 DNA 甲基化谱分析。

• 批准号: 22710067
• 负责人: TACHIBANA Ken
• 金额: $ 2.58万
• 依托单位: Tokyo University of Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22710067/
• 关键词: トキシコロジー; DNAメチル化; 環境; 衛生; エピジェネティクス; ディーゼル排ガス

Diesel exhaust(DE) was exposed to pregnant mice and genomic DNA was obtained from offspring. Subsequently, genome-wide DNA methylation analysis was performed. The results indicated that prenatal DE exposure disrupts the construction of DNA methylation pattern in the brain of offspring. It is also suggested that disrupted DNA methylation pattern is sustained during growth. Our findings provide the important information to clarify the effects and mechanisms of functional impairment of the brain induced by prenatal DE exposure.

将柴油机尾气(DE)暴露于妊娠小鼠，并从其后代中提取基因组DNA。随后，进行全基因组DNA甲基化分析。结果表明，孕期DE暴露破坏了子代大脑DNA甲基化模式的构建。这也表明，DNA甲基化模式的破坏在生长过程中持续存在。我们的研究结果为阐明孕期DE暴露所致脑功能损害的效应和机制提供了重要信息。

项目成果

胎仔期にディーゼル排ガスに曝露されたマウスにおけるDNAメチル化状態の網羅的解析

胎儿期柴油废气暴露小鼠DNA甲基化状态综合分析

• 发表时间: 2011
• 作者: 高柳皓平;立花研;秋本純芽;新海雄介;武田健
• 通讯作者: 武田健

MEK-ERK Signaling Dictates DNA-Repair Gene MGMT Expression and Temozolomide Resistance of Stem-Like Glioblastoma Cells via the MDM2-p53 Axis

• DOI: 10.1002/stem.753
• 发表时间: 2011-12-01
• 期刊: STEM CELLS
• 影响因子: 5.2
• 作者: Sato, Atsushi;Sunayama, Jun;Kitanaka, Chifumi
• 通讯作者: Kitanaka, Chifumi

FoxO3a Functions as a Key Integrator of Cellular Signals That Control Glioblastoma Stem-like Cell Differentiation and Tumorigenicity

• DOI: 10.1002/stem.696
• 发表时间: 2011-09-01
• 期刊: STEM CELLS
• 影响因子: 5.2
• 作者: Sunayama, Jun;Sato, Atsushi;Kitanaka, Chifumi
• 通讯作者: Kitanaka, Chifumi