Augmentation of UV-induced carcinogenesis by heavy metals-relationships with histone modification and repair of DNA damage

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In this study, we investigated the relationship between increased incidence of skin cancer in recent years and coexposure to environmental chemicals (especially heavy metals) plus ultraviolet rays. We showed that several kinds of heavy metals induced DNA damage. In addition of that, the amount of DNA damage generated by UV irradiation was significantly enhanced in the presence of a certain heavy metal, and the repair kinetics of that damage was also attenuated. These results indicated augmented genotoxicity by coexposure to heavy metals and UV. Here we suggested that the coexposure would be one of the causes of recent increased prevalence rate of skin cancer.