Structural studies of mammalian dimeric dihydrodiol dehydrogenase and L-xylulose reductase

研究的目的是确定哺乳动物二聚二氢二醇脱氢酶和L-木酮糖还原酶的结构和机制。 哺乳动物二氢二醇脱氢酶以多种形式存在于哺乳动物组织中。 该酶的二聚体形式具有不同于先前已知的哺乳动物酶的一级结构，并且可以与原核蛋白质一起构成新的蛋白质家族。 L-木酮糖还原酶是糖醛酸循环的酶，其占人类每天总葡萄糖代谢的约5%。 我们建议确定L-木酮糖还原酶的第一结构。

The aim of the research is determine the structures and mechanisms of mammalian dimeric dihrodiol dehydrogenase and L-xylulose reductase. Mammalian dihydrodiol dehydrogenase exists in multiple forms in mammalian tissues. The dimeric form of the enzyme has a primary structure distinct from previously known mammalian enzymes and may constitute a novel protein family with prokaryotic proteins. L-Xylulose reductase is an enzyme of the uronate cycle that accounts for about 5% of the total glucose metabolism per day in humans. We propose to determine the first structure of a L-xylulose reductase.