Database construction for transcriptional regulation in Streptomyces and Synechocystis and these applications

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Recent works in bacterial transcriptional network analysis reveal that transcriptional regulations are flexible and evolve rapidly. It is therefore important to construct reference databases on transcriptional regulation of multiple model organisms. I constructed referenced databases in Streptomyces and Synechocystis with manually collected data from nearly 500 literatures. By using the collected data, I performed comparative genome analysis and network motif analysis and suggested specificity of transcriptional networks in species-specific functions, such as antibiotic synthesis of Streptomyces and photosynthesis of Synechocystis.