Twist propagation and nonequilibrium chiral dynamics in DNA filaments during transcriptions.

转录过程中 DNA 丝的扭曲传播和非平衡手性动力学。

• 批准号: 22740274
• 负责人: WADA Hirofumi
• 金额: $ 1.66万
• 依托单位: Ritsumeikan University (2012)Kyoto University (2010-2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22740274/
• 关键词: 生物物理学; 線形弾性論; DNA メカニクス; ヌクレオソーム; 転写ダイナミク ス; DNAダイナミクス; twist-bend coupling; DNA supercoiling; 弾性フィラメント; 非衡現象; DNA転写反応; ねじれ; 非平衡現象

In this project, we studied the mechanical stabilities and responses of a DNA filament and a nucleosome-like complex against applied twist deformations using analytical and numerical methods based on continuum mechanics approaches. Our results suggest that chiral reversal and related metastable structures of a nucleosome could be produced mechanically by the functions of RNA polymerase II during DNA transcription. This study will be potentially important for understanding dynamical stability and plasticity of chromatin structures observed in living cells.

在这个项目中，我们研究了机械稳定性和响应的DNA丝和核小体复合物对应用扭曲变形的分析和数值方法的基础上连续介质力学方法。我们的研究结果表明，手性反转和相关的亚稳结构的核小体可以产生机械的功能RNA聚合酶II在DNA转录。这项研究将是潜在的重要了解动态稳定性和可塑性的染色质结构中观察到的活细胞。

项目成果

Model for gliding bacteria driven by helical flow of surface adesives

表面粘合剂螺旋流驱动的细菌滑动模型

• 作者: H. Kuwahara;S. Sudo;M. Iijima;and S. Ohya;高田慎一;石北央，斉藤圭亮;Hirofumi Wada
• 通讯作者: Hirofumi Wada

Universal bond correlation function for two-dimensional polymer rings

• DOI: 10.1209/0295-5075/91/68002
• 发表时间: 2010-09
• 期刊: EPL (Europhysics Letters)
• 作者: Takahiro Sakaue;Guillaume Witz;G. Dietler;Hirofumi Wada