Elucidation of Interfacial Structure and Functionality of the Biomembrane on the ECM

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The surface of cell membrane is typically covered by the extracellular matrix (ECM), which controls the local environment of the cell membrane surface and strongly affects functionality of the cell membrane. However, a number of issues related to the relationship of the structure and functionality of ECM are still unclear. In the present study, to understand the functionality of the ECM, the interfacial molecule structures of a series of biocompatible materials which could be employed as ECM, such as polyrotaxane supramolecules with cyclodextrin hosts, polymer electrolyte and cationic surfactant molecules, have been characterized by the sum frequency generation (SFG) vibrational spectroscopy and atomic force microscope (AFM) at a molecular level. The information obtained is useful to understand the functionality of ECM by controlling their interfacial structures.